If you've got a full-size pickup truck, chances are that at some point you're going to want to take advantage of the truck's towing capacity. Whether you want to bring a trailer to go camping or have just bought a new boat, having a hitch on the back of your truck can be extremely useful. However, drivers need to be aware of exactly how to tow before they jump into it.
Always check the towing capacity of your vehicle before you load anything up. Towing is about knowing weight limits and sticking to them religiously. Class III hitches, which are the most common, are rated for 5,000 pounds. Go above that and you're playing with fire.
As for the trailer that you use, try to find a dual-axle model. This is easier in general to control, and in the nightmare scenario of a flat tire on your trailer, it won't necessarily be the end of the world.
Beyond that, you simply need to change your driving style when you've got a trailer. Give yourself more room on turns and when changing lanes. Try to stick to open roads and avoid narrow city streets. In general, you are more restricted when you tow, your vehicle will not be as agile and you just need to get used to this. Try taking a few spins around the neighborhood, even with an empty trailer, just to get a feel for it.